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Genome-wide association studies (GWAS) have decisively shown that more than half of AMD risk is genetically determined by two major genetic loci, one on chromosome 1 encoding for complement factor H and the other related complement genes and another one on chromosome 10 encoding for the HTRA 1 and ARMS 2 genes, along with a large number of minor gene loci that can modestly enhance protection against or risk of development of AMD [76]